APD597
Cat. No.：YN321007
CAS No. ：897732-93-3
| 产品名称: | APD597 |
| CAS No.: | 897732-93-3 |
| Chemical Name: | 4-[[5-methoxy-6-[[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino]-4-pyrimidinyl]oxy]-1-piperidinecarboxylic acid, 1-methylethyl ester |
| Synonyms: | JNJ-38431055 |
| 分子量: | 479.55 |
| 分子式: | C₂₁H₂₉N₅O₆S |
| SMILES: | O=C(OC(C)C)N(CC1)CCC1OC2=C(OC)C(NC3=CC=C(S(=O)(C)=O)N=C3C)=NC=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | APD597 (JNJ-38431055) 是 GPR119 激动剂, 作用于 hGPR119, EC50 为 46 nM, 可用于研究 2 型糖尿病。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Semple, G., Lehmann, J., Wong, A., et al.Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profileBioorg. Med. Chem. Lett.22(4),1750-1755(2012)
Huan, Y., Jiang, Q., Li, G., et al.The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivoSci. Rep.7(1),4351(2017)
