PSN632408
Cat. No.：YN321077
| 产品名称: | PSN632408 |
| CAS No.: | 857652-30-3 |
| Chemical Name: | 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester |
| Synonyms: | PSN 632408; PSN-632408, PSN 632408; PSN-632408 |
| 分子量: | 360.41 |
| 分子式: | C₁₈H₂₄N₄O₄ |
| SMILES: | O=C(OC(C)(C)C)N1CCC(CC1)OCC2=NC(C3=CC=NC=C3)=NO2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PSN632408 是一种选择性的口服活性GPR119激动剂，在重组小鼠和人GPR119 受体上显示出与 OEA 相似的效力 (EC50=5.6 和 7.9 uM)。PSN632408 可以刺激 β 细胞复制并改善胰岛移植功能。PSN632408 具有研究肥胖症和相关代谢异常的潜力。 |
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Fu, J., Gaetani, S., Oveisi, F., et al.Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-αNature425(6953),90-93(2003)
Overton, H.A., Babbs, A.J., Doel, S.M., et al.Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agentsCell Metab.3(3),167-175(2006)
