TUG-891
Cat. No.：YN320086
CAS No. ：1374516-07-0
| 产品名称: | TUG-891 |
| CAS No.: | 1374516-07-0 |
| Chemical Name: | 4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid |
| Synonyms: | TUG891,TUG 891 |
| 分子量: | 364.41 |
| 分子式: | C₂₃H₂₁FO₃ |
| SMILES: | O=C(O)CCC1=CC=C(OCC2=CC(F)=CC=C2C3=CC=C(C)C=C3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TUG-891 是有效的，选择性的长链游离脂肪酸受体 4 (FFA4/GPR120) 的激动剂。 |
| IC50和靶点: | |
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Shimpukade, B., Hudson, B.D., Hovgaard, C.K., et al.Discovery of a potent and selective GPR120 agonistJ. Med. Chem.55(9),4511-4515(2012)
Liu, Z., Hopkins, M.M., Zhang, Z., et al.Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cellsJ. Pharmacol. Exp. Ther.352(2),380-394(2015)
Hudson, B.D., Shimpukade, B., Mackenzie, A.E., et al.The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonismMol. Pharmacol.84(5),710-725(2013)
Gozal, D., Qiao, Z., Almendros, I., et al.Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in miceInt. J. Obes. (Lond.)40(7),1143-1149(2016)
