GSK137647A
Cat. No.：YN321261
CAS No. ：349085-82-1
| 产品名称: | GSK137647A |
| CAS No.: | 349085-82-1 |
| Chemical Name: | 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide |
| Synonyms: | GSK 137647 |
| 分子量: | 305.39 |
| 分子式: | C₁₆H₁₉NO₃S |
| SMILES: | O=S(C1=CC=C(OC)C=C1)(NC2=C(C)C=C(C)C=C2C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK137647A是选择性FFA4激动剂，作用于人类，小鼠和大鼠FFA4的pEC50分别为6.3，6.2和6.1。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Davenport, A.P., Alexander, S.P.H., Sharman, J.L., et al.International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligandsPharmacol. Rev.65(3),967-986(2013)
Oh, D.Y., Talukdar, S., Bae, E.J., et al.GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin sensitizing effectsCell142(5),687-698(2010)
Martin, C., Passilly-Degrace, P., Chevrot, M., et al.Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: Putative involvement of GPR120 and impact on taste sensitivityJ. Lipid Res.53(11),2256-2265(2012)
Sparks, S.M., Chen, G., Collins, J.L., et al.Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)Bioorg. Med. Chem. Lett.24,3100-3103(2014)
