MEDICA16
Cat. No.：YN321852
CAS No. ：87272-20-6
| 产品名称: | MEDICA16 |
| CAS No.: | 87272-20-6 |
| Chemical Name: | 3,3,14,14-tetramethylhexadecanedioic acid |
| Synonyms: | MEDICA 16 |
| 分子量: | 342.51 |
| 分子式: | C₂₀H₃₈O₄ |
| SMILES: | O=C(O)CC(C)(C)CCCCCCCCCCC(C)(C)CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MEDICA16 是一种ATP-citrate lyase抑制剂，能显著降低腓肠肌细胞内 TG 的含量，这种降低伴随着胰岛素敏感性的增加。MEDICA16 是GPR40的选择性激动剂，也是GPR120的选择性部分激动剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hara, T., Hirasawa, A., Sun, Q., et al.Novel selective ligands for free fatty acid receptors GPR120 and GPR40Naunyn Schmiedebergs Arch Pharmacol.380(3),247-255(2009)
Wells, T.N.C., and Saxty, B.A.Redox control of catalysis in ATP-citrate lyase from rat liverEur. J. Biochem.204(1),249-255(1992)
Atkinson, L.L., Kelly, S.E., Russell, J.C., et al.MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp ratsDiabetes51(5),1548-1555(2002)
Russell, J.C., Shillabeer, G., Bar-Tana, J., et al.Development of insulin resistance in the JCR:LA-cp rat: Role of triacylglycerols and effects of MEDICA 16Diabetes47(5),770-778(1998)
