JNJ-63533054
Cat. No.：YN321249
CAS No. ：1802326-66-4
| 产品名称: | JNJ-63533054 |
| CAS No.: | 1802326-66-4 |
| Chemical Name: | 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]-benzamide |
| Synonyms: | JNJ 63533054 |
| 分子量: | 316.78 |
| 分子式: | C₁₇H₁₇ClN₂O₂ |
| SMILES: | O=C(NCC(N[C@H](C1=CC=CC=C1)C)=O)C2=CC=CC(Cl)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-63533054 是一种有效的，选择性的，具有口服活性的GPR139激动剂，对人GPR139的EC50为 16 nM。JNJ-63533054 对 GPR139 的选择性高于其他 GPCR，离子通道和转运蛋白。JNJ-63533054 可以穿过血脑屏障 (BBB)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Dvorak, C.A., Coate, H., Nepomuceno, D., et al.Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptorACS Med. Chem. Lett.6(9),1015-1018(2015)
Liu, C., Bonaventure, P., Lee, G., et al.GPR139, an orphan receptor highly enriched in the habenula and septum, is activated by the essential amino acids L-Tryptophan and L-PhenylalanineMol. Pharmacol.88(5),911-925(2015)
