GW9508
Cat. No.：YN321010
CAS No. ：885101-89-3
| 产品名称: | GW9508 |
| CAS No.: | 885101-89-3 |
| Chemical Name: | 4-[[(3-phenoxyphenyl)methyl]amino]-benzenepropanoic acid |
| Synonyms: | GW 9508 |
| 分子量: | 347.41 |
| 分子式: | C₂₂H₂₁NO₃ |
| SMILES: | O=C(O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW9508 是一种有效的选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR40激动剂，pEC50值分别为 7.32 和 5.46。GW9508 对GPR40的选择性是GPR120的 100 倍左右，对其他 GPCR，激酶，蛋白酶，整联蛋白和 PPAR 无活性。GW9508 是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾 (KATP) 通道开放剂。GW9508 具有抗炎和抗动脉粥样硬化活性。 |
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Briscoe, C.P., Peat, A.J., McKeown, S.C., et al.Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small moleculesBr. J. Pharmacol.148(5),619-628(2006)
Li, M., Meng, X., Xu, J., et al.GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathwaySci. Rep.6:25237,(2016)
