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Vincamine

Cat. No.:YN321599

  • CAS No. :1617-90-9

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Vincamine
      CAS No.: 1617-90-9
      Chemical Name: (3α,14β,16α)-14,15-dihydro-14-hydroxy-eburnamenine-14-carboxylic acid, methyl ester
      Synonyms:长春胺
      分子量:354.44
      分子式:C₂₁H₂₆N₂O₃
      SMILES:O=C(OC)[C@@]1(O)C[C@@]2(CC)[C@@]3([H])C(N1C4=CC=CC=C54)=C5CCN3CCC2
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Vincamine 是从马达加斯加长春花中提取的单萜吲哚生物碱。Vincamine 是GPR40激动剂,通过改善细胞功能障碍和促进葡萄糖刺激的胰岛素分泌 (GSIS),起到 β 细胞保护剂的作用。Vincamine 改善体内葡萄糖稳态,有潜力用于 2 型糖尿病 (T2DM) 研究。Vincamine 是一种外周血管扩张剂 (vasodilator),对微血管循环,特别是在大脑中,有选择性的血管调节作用。
      IC50和靶点:
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    • Lim, C.C., and James, I.M.The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteersBr. J. Clin. Pharmacol.9(1),100-101(1980)

      Young, A.R., Bouloy, M., Boussard, J.F., et al.Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vesselsJ. Cereb. Blood Flow Metab.1(1),117-128(1981)

      Nowicki, J.P., MacKenzie, E.T., and Spinnewyn, B.Effects of agents used in the pharmacotherapy of cerebrovascular disease on the oxygen consumption of isolated cerebral mitochondriaJ. Cereb. Blood Flow Metab.2(1),33-40(1982)

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