CID 16020046
Cat. No.：YN321082
| 产品名称: | CID 16020046 |
| CAS No.: | 834903-43-4 |
| Chemical Name: | 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-benzoic acid |
| Synonyms: | C390-0219 |
| 分子量: | 425.44 |
| 分子式: | C₂₅H₁₉N₃O₄ |
| SMILES: | O=C(O)C1=CC=C(N(C2C3=CC=CC(O)=C3)C(C4=C2C(C5=CC=C(C)C=C5)=NN4)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CID 16020046 是一种有效的，选择性GPR55拮抗剂，抑制 GPR55 的组成型活性，IC50为 0.15 μM。CID 16020046 抑制 GPR55 介导的 Ca2+信号传导和 GPR55 介导的 ERK1/2 磷酸化。CID 16020046 降低了内皮细胞的伤口愈合，并参与了血小板功能的调节。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kargl, J., Brown, A.J., Andersen, L., et al.A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell functionJ. Pharmacol. Exp. Ther.346(1),54-66(2013)
