1-Azakenpaullone
Cat. No.：YN420280
| 产品名称: | 1-Azakenpaullone |
| CAS No.: | 676596-65-9 |
| Chemical Name: | 9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one |
| Synonyms: | 1-Akp |
| 分子量: | 328.16 |
| 分子式: | C₁₅H₁₀BrN₃O |
| SMILES: | O=C(NC1=CC=CN=C12)CC3=C2NC4=C3C=C(Br)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 1-Azakenpaullone (1-Akp) 是具有高度选择性的、ATP 竞争性的糖原合成酶激酶3 β (GSK-3β)的抑制剂，其IC50值为 18 nM。 |
| IC50和靶点: | [{name:"GSK-3β:18 nM (IC50)"},{name: "CDK1/cyclin B:2 μM (IC50)"},{name: "CDK5/p25:4.2 μM (IC50)"}] |
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Kunick, C., Lauenroth, K., Leost, M., et al.1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3βBioorg. Med. Chem. Lett.14(2),413-416(2004)
Liu, H., Remedi, M.S., Pappan, K.L., et al.Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human isletsDiabetes58(3),663-672(2009)
Mfopou, J.K., Geeraerts, M., Dejene, R., et al.Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studiesStem Cell Res.12(1),166-177(2014)
Marlow, H., Matus, D.Q., and Martindale, M.Q.Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensisDev. Biol.380(2),324-334(2013)
