R547
Cat. No.：YN420004
CAS No. ：741713-40-6
规格
价格(RMB)
库存
| 产品名称: | R547 |
| CAS No.: | 741713-40-6 |
| Chemical Name: | [4-amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)-methanone |
| Synonyms: | Ro 4584820 |
| 分子量: | 441.45 |
| 分子式: | C₁₈H₂₁F₂N₅O₄S |
| SMILES: | O=S(N1CCC(NC2=NC(N)=C(C(C3=C(C(F)=CC=C3OC)F)=O)C=N2)CC1)(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | R547 是一种高效、选择性的，口服有效的 ATP 竞争性的CDK抑制剂，对 CDK1/cyclin B、 CDK2/cyclin E 和 CDK4/cyclin D1 作用的Ki值分别为 2 nM、3 nM、1 nM。 |
| IC50和靶点: | [{name:"Cdk1/cyclin B:2 nM (Ki)"},{name: "CDK2/cyclinE:3 nM (Ki)"},{name: "CDK4/cyclin D:1 nM (Ki)"},{name: "cdk2/cyclin A:0.1 nM (IC50)"},{name: "CDK2/cyclinE:0.4 nM (IC50)"},{name: "Cdk1/cyclin B:0.2 nM (IC50)"},{name: "CDK3/Cyclin E:0.8 nM (IC50)"},{name: "CDK5/p35:0.1 nM (IC50)"},{name: "cdk6/cyclin D3:4 nM (IC50)"},{name: "CDK7/cyclin H:171 nM (IC50)"},{name: "GSK-3α:46 nM (IC50)"},{name: "GSK-3β:260 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
DePinto, W., Chu, X.J., Yin, X., et al.In vitro and in vivo activity of R547: A potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trialsMol. Cancer Ther.5(11),2644-2658(2006)
