CP21R7
Cat. No.：YN420006
CAS No. ：125314-13-8
规格
价格(RMB)
库存
| 产品名称: | CP21R7 |
| CAS No.: | 125314-13-8 |
| Chemical Name: | 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Synonyms: | CP21 |
| 分子量: | 317.34 |
| 分子式: | C₁₉H₁₅N₃O₂ |
| SMILES: | O=C1C(C2=CN(C)C3=CC=CC=C23)=C(C4=CC(N)=CC=C4)C(N1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP21R7 是一种有效的GSK-3β抑制剂，IC50值为 1.8 nM；CP21R7 同时可抑制PKCα，IC50值为 1900 nM。 |
| IC50和靶点: | [{name:"GSK-3β:1.8 nM (IC50)"},{name: "PKCα:1900 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gong, L., Hirschfeld, D., Tan, Y.-C., et al.Discovery of potent and bioavailable GSK-3β inhibitorsBioorg. Med. Chem. Lett.20(5),1693-1696(2010)
Christensen, K., Graf, M., Iacone, R., et al.Method for differentiation of pluripotent stem cells into vascular bed cells,(2015)
Patsch, C., Challet-Meylan, L., Thoma, E.C., et al.Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cellsNat. Cell Biol.17(8),994-1003(2015)
Sahara, M., Hansson, E.M., Wernet, O., et al.Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cellsCell Res.24(7),820-841(2014)
