CHIR-99021
Cat. No.：YN420029
CAS No. ：252917-06-9
规格
价格(RMB)
库存
| 产品名称: | CHIR-99021 |
| CAS No.: | 252917-06-9 |
| Chemical Name: | 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Synonyms: | CT99021 |
| 分子量: | 465.34 |
| 分子式: | C₂₂H₁₈Cl₂N₈ |
| SMILES: | N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHIR-99021 (CT99021) 是一种有效的选择性GSK-3α/β抑制剂，IC50为 10 nM 和 6.7 nM。CHIR-99021 对GSK-3的选择性比 CDC2，ERK2 和其他蛋白激酶高 500 倍以上。CHIR-99021 还是一种有效的Wnt/β-catenin信号通路激活剂。CHIR-99021 可增强小鼠和人类胚胎干细胞的自我更新。CHIR-99021 能诱导细胞自噬 (autophagy)。 |
| IC50和靶点: | [{name:"GSK-3β:6.7 nM (IC50)"},{name: "GSK-3α:10 nM (IC50)"},{name: "CDC2:8800 nM (IC50)"}] |
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| Solvent & Solubility: |
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