CHIR-99021 trihydrochloride
Cat. No.：YN420031
CAS No. ：1782235-14-6
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| 产品名称: | CHIR-99021 trihydrochloride |
| CAS No.: | 1782235-14-6 |
| Chemical Name: | |
| Synonyms: | CT99021 trihydrochloride |
| 分子量: | 574.72 |
| 分子式: | C₂₂H₂₁Cl₅N₈ |
| SMILES: | N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHIR-99021 trihydrochloride (CT99021 trihydrochloride) 是一种有效的选择性GSK-3α/β抑制剂，IC50为 10 nM 和 6.7 nM。CHIR-99021 trihydrochloride 对GSK-3的选择性比 CDC2，ERK2 和其他蛋白激酶高 500 倍以上。CHIR-99021 trihydrochloride 还是一种有效的Wnt/β-catenin信号通路激活剂。CHIR-99021 trihydrochloride 可增强小鼠和人 |
| IC50和靶点: | [{name:"GSK-3β:6.7 nM (IC50)"},{name: "GSK-3α:10 nM (IC50)"},{name: "cdc2:8800 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
