K00546
Cat. No.：YN420043
CAS No. ：443798-47-8
规格
价格(RMB)
库存
| 产品名称: | K00546 |
| CAS No.: | 443798-47-8 |
| Chemical Name: | 5-amino-3-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide |
| Synonyms: | K 00546 |
| 分子量: | 425.44 |
| 分子式: | C₁₅H₁₃F₂N₇O₂S₂ |
| SMILES: | S=C(N1N=C(NC2=CC=C(S(=O)(N)=O)C=C2)N=C1N)NC3=C(F)C=CC=C3F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | K00546 是一种有效的CDK1和CDK2抑制剂，对CDK1/cyclin B和CDK2/cyclin A的IC50分别为 0.6 nM 和 0.5 nM。K00546 也是一种有效的 CDC2 样激酶 1 (CLK1) 和CLK3抑制剂，IC50分别为 8.9 nM 和 29.2 nM。 |
| IC50和靶点: | [{name:"Cdk1/cyclin B:0.6 nM (IC50)"},{name: "cdk2/cyclin A:0.5 nM (IC50)"},{name: "CLK1:8.9 nM (IC50)"},{name: "CLK3:29.2 nM (IC50)"},{name: "VEGF-R2:32 nM (IC50)"},{name: "GSK-3:140 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Bettayeb, K., Baunbaek, D., Delehouze, C., et al.CDK inhibitors roscovitine and CR8 trigger Mcl-I down-regulation and apoptotic cell death in neuroblastoma cellsGenes Cancer1(4),369-380(2010)
Lin, R., Connolly, P.J., Huang, S., et al.1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: Synthesis and evaluation of biological activitiesJ. Med. Chem.48(13),4208-4211(2005)
Fedorov, O., Huber, K., Eisenreich, A., et al.Specific CLK inhibitors from a novel chemotype for regulation of alternative splicingChem. Biol.18(1),67-76(2011)
