A 1070722
Cat. No.：YN420058
CAS No. ：1384424-80-9
规格
价格(RMB)
库存
| 产品名称: | A 1070722 |
| CAS No.: | 1384424-80-9 |
| Chemical Name: | N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-urea |
| Synonyms: | |
| 分子量: | 362.31 |
| 分子式: | C₁₇H₁₃F₃N₄O₂ |
| SMILES: | FC(F)(F)C1=NC(NC(NC2=CC=NC3=C2C=CC(OC)=C3)=O)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A 1070722 是一个高效、选择性的糖原合成酶激酶 3(GSK-3)抑制剂，对 GSK-3α 和 GSK-3β 作用的Ki为 0.6 nM。A 1070722 能穿透血脑屏障并在脑区积聚，具有作为定量测定脑部 GSK-3 的 PET 放射性跟踪剂的潜力。 |
| IC50和靶点: | [{name:"GSK-3α:0.6 nM (Ki)"},{name: "GSK-3β:0.6 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Turner, S.C., Mack, H., Bakker, M.H.M., et al.Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors,(2012)
