Alsterpaullone
Cat. No.：YN420062
CAS No. ：237430-03-4
规格
价格(RMB)
库存
| 产品名称: | Alsterpaullone |
| CAS No.: | 237430-03-4 |
| Chemical Name: | 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one |
| Synonyms: | 9-Nitropaullone; NSC 705701 |
| 分子量: | 293.28 |
| 分子式: | C₁₆H₁₁N₃O₃ |
| SMILES: | O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alsterpaullone (9-Nitropaullone) 是一种高效的CDK抑制剂，作用于 CDK1/cyclin B、CDK2/cyclin A、CDK2/cyclin E 和 CDK5/p35 的IC50值分别为 35 nM、15 nM、200 nM 和 40 nM。Alsterpaullone 是 ATP 竞争性的GSK-3alpha/GSK-3beta抑制剂，且作用的IC50值都为 4 nM。Alsterpaullone 具有抗肿瘤活性，有用于神经退行性和增生性疾病研究的潜力。 |
| IC50和靶点: | [{name:"Cdk1/cyclin B:35 nM (IC50)"},{name: "cdk2/cyclin A:15 nM (IC50)"},{name: "CDK2/Cyc E:200 nM (IC50)"},{name: "CDK5/p35:40 nM (IC50)"},{name: "GSK-3α:4 (IC50)"},{name: "GSK-3β:4 nM (IC50)"}] |
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