TDZD-8
Cat. No.：YN420070
CAS No. ：327036-89-5
规格
价格(RMB)
库存
| 产品名称: | TDZD-8 |
| CAS No.: | 327036-89-5 |
| Chemical Name: | 2-methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione |
| Synonyms: | GSK-3β Inhibitor I; NP 01139 |
| 分子量: | 222.26 |
| 分子式: | C₁₀H₁₀N₂O₂S |
| SMILES: | O=C(N1CC2=CC=CC=C2)N(C)SC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TDZD-8 是GSK-3β的抑制剂，IC50为 2 μM；TDZD-8 对 Cdk-1/cyclin B，CK-II，PKA 和 PKC 的作用较弱，IC50值均 >100 μM。 |
| IC50和靶点: | [{name:"GSK-3β:2 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Martinez, A., Alonso, M., Castro, A., et al.First non-ATP competitive glycogen synthase kinase 3 β (GSK-3β) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's diseaseJ. Med. Chem.45(6),1292-1299(2002)
Guzman, M.L., Li, X., Corbett, C.A., et al.Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)Blood110(13),4436-4444(2007)
Eldar-Finkelman, H., and Martinez, A.GSK-3 inhibitors: Preclinical and clinical focus on CNSFront. Mol. Neurosci.4,32(2011)
