SB 216763
Cat. No.：YN420100
CAS No. ：280744-09-4
规格
价格(RMB)
库存
| 产品名称: | SB 216763 |
| CAS No.: | 280744-09-4 |
| Chemical Name: | 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Synonyms: | SB216763 |
| 分子量: | 371.22 |
| 分子式: | C₁₉H₁₂Cl₂N₂O₂ |
| SMILES: | O=C(NC1=O)C(C2=CC=C(C=C2Cl)Cl)=C1C3=CN(C4=C3C=CC=C4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB 216763是有效，选择性和ATP竞争性的GSK-3抑制剂，抑制GSK-3α和GSK-3β的IC50为34.3 nM。 |
| IC50和靶点: | [{name:"GSK-3α:34.3 nM (IC50)"},{name: "GSK-3β:34.3 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Coghlan, M.P., Culbert, A.A., Cross, D.A.E., et al.Selective small molecule inhibitors or glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionChem. Biol.7(10),793-803(2000)
Cross, D.A.E., Culbert, A.A., Chalmers, K.A., et al.Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from deathJ. Neurochem.77,94-102(2001)
