Kenpaullone
Cat. No.：YN420119
CAS No. ：142273-20-9
规格
价格(RMB)
库存
| 产品名称: | Kenpaullone |
| CAS No.: | 142273-20-9 |
| Chemical Name: | 9-bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one |
| Synonyms: | 9-Bromopaullone; NSC-664704 |
| 分子量: | 327.18 |
| 分子式: | C₁₆H₁₁BrN₂O |
| SMILES: | O=C1NC2=CC=CC=C2C(NC3=C4C=C(Br)C=C3)=C4C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Kenpaullone 是一种有效的CDK1/cyclin B和GSK-3β抑制剂，IC50值分别为 0.4 μM 和 23 nM，同时可抑制 CDK2/cyclin A，CDK2/cyclin E 和 CDK5/p25 的活性，IC50值分别为 0.68 μM，7.5 μM 和 0.85 μM。 |
| IC50和靶点: | [{name:"Cdk1/cyclin B:0.4 μM (IC50)"},{name: "cdk2/cyclin A:0.68 μM (IC50)"},{name: "CDK5/p35:0.85 μM (IC50)"},{name: "CDK2/cyclinE:7.5 μM (IC50)"},{name: "GSK-3β:0.023 μM (IC50)"},{name: "erk1:20 μM (IC50)"},{name: "erk2:9 μM (IC50)"},{name: "c-raf:38 μM (IC50)"}] |
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| Solvent & Solubility: |
Zaharevitz, D.W., Gussio, R., Leost, M., et al.Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinasesCancer Res.59(11),2566-2569(1999)
Bain, J., McLauchlan, H., Elliot, M., et al.The specificities of protein kinase inhibitors: An updateBiochem. J.371(Pt. 1),199-204(2003)
LeClerc, S., Garnier, M., Hoessel, R., et al.Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?J. Biol. Chem.276(1),251-260(2001)
