GNF4877
Cat. No.：YN420145
CAS No. ：2041073-22-5
规格
价格(RMB)
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| 产品名称: | GNF4877 |
| CAS No.: | 2041073-22-5 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 494.52 |
| 分子式: | C₂₅H₂₇FN₆O₄ |
| SMILES: | O=C([C@H]1CN(C2=C(NC(C3=NC(C4=CC(OC(C)C)=CC=C4F)=CN=C3N)=O)C=NC=C2)CCC1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNF4877是DYRK1A和GSK3β的有效抑制剂，IC50值分别为 6 nM 和 16 nM，可导致 NFATc 核输出受阻并增加 β 细胞增殖 (对小鼠 β (R7T1) 细胞的EC50值为 0.66 μM)。 |
| IC50和靶点: | [{name:"GSK3β:16 nM (IC50)"},{name: "DYRK1A:6 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
