CHIR-98014
Cat. No.：YN420150
CAS No. ：252935-94-7
规格
价格(RMB)
库存
| 产品名称: | CHIR-98014 |
| CAS No.: | 252935-94-7 |
| Chemical Name: | N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine |
| Synonyms: | CT98014 |
| 分子量: | 486.31 |
| 分子式: | C₂₀H₁₇Cl₂N₉O₂ |
| SMILES: | ClC1=CC(Cl)=CC=C1C2=NC(NCCNC3=CC=C([N+]([O-])=O)C(N)=N3)=NC=C2N4C=CN=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHIR-98014 是一种有效的，细胞通透的GSK-3抑制剂，可抑制GSK-3α和GSK-3β的活性，IC50值分别为 0.65 和 0.58 nM；CHIR-98014 对 cdc2 和 erk2 的作用较弱。 |
| IC50和靶点: | [{name:"GSK-3β:0.58 nM (IC50)"},{name: "GSK-3α:0.65 nM (IC50)"},{name: "cdc2:3700 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ring, D.B., Johnson, K.W., Henriksen, E.J., et al.Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivoDiabetes52(3),588-595(2003)
Asuni, A.A., Hooper, C., Reynolds, C.H., et al.GSK3α exhibits β-catenin and tau directed kinase activities that are modulated by WntEur. J. Neurosci.24(12),3387-3392(2006)
Phiel, C.J., Wilson, C.A., Lee, V.M., et al.GSK-3α regulates production of Alzheimer's disease amyloid-β peptidesNature423(6938),435-439(2003)
Guerrero, F., Herencia, C., Almadén, Y., et al.TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathwaysPLoS One9(2),e89179(2014)
Selenica, M.L., Jensen, H.S., Larsen, A.K., et al.Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylationBr J Pharmacol. Br. J. Pharmacol.152(6),959-979(2007)
