KY19382
Cat. No.：YN420153
CAS No. ：2226664-93-1
规格
价格(RMB)
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| 产品名称: | KY19382 |
| CAS No.: | 2226664-93-1 |
| Chemical Name: | 5,6-Dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one; |
| Synonyms: | A3051 |
| 分子量: | 360.19 |
| 分子式: | C₁₇H₁₁Cl₂N₃O₂ |
| SMILES: | O=C1NC2=C(C=C(Cl)C(Cl)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KY19382 是一种有效的和具有口服活性的CXXC5-DVL和GSK3β的双重抑制剂，IC50值分别为 19 和 10 nM。KY19382 通过对 CXXC5-DVL 相互作用和 GSK3β 活性的抑制作用激活 Wnt/β-catenin 信号传导。KY19382 可用于高脂饮食 (HFD) 诱发的代谢性疾病的研究。 |
| IC50和靶点: | [{name:"CXXC5-DVL:19 nM (IC50)"},{name: "GSK3β:10 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Choi, K., et al.: From PCT Int. Appl. (2021), WO 2021090172 A1 20210514
