Desisobutyryl-ciclesonide
Cat. No.：YN320441
| 产品名称: | Desisobutyryl-ciclesonide |
| CAS No.: | 161115-59-9 |
| Chemical Name: | 16α,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11β,21-dihydroxy-pregna-1,4-diene-3,20-dione |
| Synonyms: | CIC-AP; Ciclesonide active principle |
| 分子量: | 470.60 |
| 分子式: | C₂₈H₃₈O₆ |
| SMILES: | C[C@@]12[C@@]3(C(CO)=O)[C@@](O[C@H](O3)C4CCCCC4)([H])C[C@@]1([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5([H])[C@@H](O)C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Desisobutyryl-ciclesonide 是 Ciclesonide 的活性代谢产物。Desisobutyryl-ciclesonide 对糖皮质激素受体 (glucocorticoid receptor) 具有亲和力。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Belvisi, M.G., Bundschuh, D.S., Stoeck, M., et al.Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthmaJ. Pharmacol. Exp. Ther.314(2),568-574(2005)
Joshi, T., Johnson, M., Newton, R., et al.An analysis of glucocorticoid receptor-mediated gene expression in BEAS-2B human airway epithelial cells identifies distinct, ligand-directed, transcription profiles with implications for asthma therapeuticsBr. J. Pharmacol.172(5),1360-1378(2015)
Stoeck, M., Riedel, R.T., Hochhaus, G., et al.In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonideJ. Pharmacol. Exp. Ther.309(1),249-258(2004)
