Dexamethasone palmitate
Cat. No.：YN320664
CAS No. ：14899-36-6
| 产品名称: | Dexamethasone palmitate |
| CAS No.: | 14899-36-6 |
| Chemical Name: | 9-fluoro-11β,17-dihydroxy-16α-methyl-21-[(1-oxohexadecyl)oxy]-pregna-1,4-diene-3,20-dione |
| Synonyms: | 地塞米松棕榈酸酯; DXP |
| 分子量: | 630.87 |
| 分子式: | C₃₈H₅₉FO₆ |
| SMILES: | C[C@@]12[C@](C[C@@H](C)[C@]2(O)C(COC(CCCCCCCCCCCCCCC)=O)=O)([H])[C@@]3([H])[C@@](F)([C@@]4(C(CC3)=CC(C=C4)=O)C)[C@@H](O)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dexamethasone palmitate (DXP) 是 Dexamethasone 的前药。Dexamethasone_x000D_ 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。Dexamethasone palmitate (DXP) 对糖皮质激素受体的亲和力比 Dexamethasone 低 47 倍。具有抗炎活性。 |
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Daull, P., Paterson, C.A., Kuppermann, B.D., et al.A preliminary evaluation of dexamethasone palmitate emulsion: A novel intravitreal sustained delivery of corticosteroid for treatment of macular edemaJ. Ocul. Pharmacol. Ther.29(2),258-269(2013)
Rosseau, G.G., Kirchhoff, J., Formstecher, P., et al.17β-carboxamide steroids are a new class of glucocorticoid antagonistsNature279(5709),158-160(1979)
Lorscheider, M., Tsapis, N., ur-Rehman, M., et al.Dexamethasone palmitate nanoparticles: An efficient treatment for rheumatoid arthritisJ. Control. Release296,179-189(2019)
