Dexamethasone
Cat. No.：YN320900
| 产品名称: | Dexamethasone |
| CAS No.: | 50-02-2 |
| Chemical Name: | 9-fluoro-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione |
| Synonyms: | 地塞米松; Hexadecadrol; Prednisolone F |
| 分子量: | 392.46 |
| 分子式: | C₂₂H₂₉FO₅ |
| SMILES: | O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@]4(C(CO)=O)O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。Dexamethasone 还显着降低中性粒细胞的 CD11b，CD18 和 CD62L 表达，以及单核细胞的 CD11b 和 CD18 表达。Dexamethasone 有潜力用于 COVID-19 的研究。Dexamethasone在LPS诱导的巨噬细胞炎症反应中，抑制含有炎性 miRNA-155 的外泌体的产生。 |
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Mulatero, P., Panarelli, M., Schiavone, D., et al.Impaired cortisol binding to glucocorticoid receptors in hypertensive patientsHypertension30(5),1274-1278(1997)
Beck, I.M., Vanden Berghe, W., Vermeulen, L., et al.Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatasesEndocr. Rev.30(7),830-882(2009)
