Fluticasone furoate
Cat. No.：YN320948
CAS No. ：397864-44-7
| 产品名称: | Fluticasone furoate |
| CAS No.: | 397864-44-7 |
| Chemical Name: | (6α,11β,16α,17α)-6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carbothioic acid, S-(fluoromethyl) ester |
| Synonyms: | 糠酸氟替卡松 |
| 分子量: | 538.58 |
| 分子式: | C₂₇H₂₉F₃O₆S |
| SMILES: | C[C@@]12[C@](C(SCF)=O)(OC(C3=CC=CO3)=O)[C@H](C)C[C@@]1([H])[C@]4([H])C[C@H](F)C5=CC(C=C[C@]5(C)[C@@]4(F)[C@@H](O)C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fluticasone furoate 是一种局部，鼻内，增强亲和力的合成的三氟皮质类固醇，Kd为 0.3 nM。Fluticasone furoate 具有有效的抗炎和抗哮喘活性，并且全身暴露率低。Fluticasone furoate 可用于过敏性鼻炎的研究。 |
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Salter, M., Biggadike, K., Matthews, J.L., et al.Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory diseaseAm. J. Physiol. Lung Cell Mol. Physiol.293(3),L660-L667(2007)
Zhang, N., Van Crombruggen, K., Holtappels, G., et al.Suppression of cytokine release by fluticasone furoate vs. mometasone furoate in human nasal tissue ex-vivoPLoS One9(4):e93754,(2014)
