Fluticasone (propionate)
Cat. No.：YN321396
CAS No. ：80474-14-2
| 产品名称: | Fluticasone (propionate) |
| CAS No.: | 80474-14-2 |
| Chemical Name: | (6α,11β,16α,17α)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid, S-(fluoromethyl) ester |
| Synonyms: | 丙酸氟替卡松 |
| 分子量: | 500.57 |
| 分子式: | C₂₅H₃₁F₃O₅S |
| SMILES: | O=C(CC)O[C@@]([C@]([C@@]1([H])C2)(C[C@H](O)[C@](F)([C@]3(C=C4)C)[C@@]1([H])C[C@H](F)C3=CC4=O)C)([C@@H]2C)C(SCF)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fluticasone propionate 是一种有效的局部抗炎激素，一种选择性的糖皮质激素受体 (glucocorticoid receptor) 激动剂，绝对亲和力KD为 0.5 nM。Fluticasone propionate 在其他甾体受体上几乎没有活性。具有抗病毒活性。 |
| IC50和靶点: | |
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Hemmerling, M., Nilsson, S., Edman, K., et al.Selective nonsteroidal glucocorticoid receptor modulators for the inhaled treatment of pulmonary diseasesJ. Med. Chem.60(20),8591-8605(2017)
Pace, E., Gagliardo, R., Melis, M., et al.Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthmaJ. Allergy. Clin. Immunol.114(5),1216-1223(2004)
Zhang, X., Moilanen, E., and Kankaanranta, H.Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasoneEur. J. Pharmacol.406(3),325-332(2000)
Bahekar, P.C., Shah, J.H., Ayer, U.B., et al.Validation of guinea pig model of allergic rhinitis by oral and topical drugsInt. Immunopharmacol.8(11),1540-1551(2008)
Pan, Y., Levin, E.J., Quick, M., et al.Potentiation of the Kv1 family K+ channel by cortisone analoguesACS Chem. Biol.7(10),1641-1646(2012)
