LY2365109 hydrochloride
Cat. No.：YN360029
CAS No. ：1779796-27-8
| 产品名称: | LY2365109 hydrochloride |
| CAS No.: | 1779796-27-8 |
| Chemical Name: | N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methyl-glycine, monohydrochloride |
| Synonyms: | LY2365109盐酸盐 |
| 分子量: | 421.91 |
| 分子式: | C₂₂H₂₈ClNO₅ |
| SMILES: | O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY2365109 hydrochloride 是一种高效、选择性的GlyT1抑制剂，抑制过表达 hGlyT1 细胞摄取谷氨酸的IC50值为 15.8 nM. |
| IC50和靶点: | [{name:"hGlyT1:15.8 nM nM (IC50)"}] |
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| Solvent & Solubility: |
Perry, K.W., Falcone, J.F., Fell, M.J., et al.Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areasNeuropharmacology55(5),743-754(2008)
Shen, H.-Y., van Vliet, E.A., Bright, K.-A., et al.Glycine transporter 1 is a target for the treatment of epilepsyNeuropharmacology99,554-565(2015)
