Cinaciguat hydrochloride
Cat. No.：YN320830
| 产品名称: | Cinaciguat hydrochloride |
| CAS No.: | 646995-35-9 |
| Chemical Name: | 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid, monohydrochloride |
| Synonyms: | BAY 58-2667 hydrochloride |
| 分子量: | 602.16 |
| 分子式: | C₃₆H₄₀ClNO₅ |
| SMILES: | OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC(C=CC=C2)=C2OCC(C=C3)=CC=C3CCC4=CC=CC=C4)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cinaciguat hydrochloride 是一种有效的可溶性鸟苷酸环化酶 (GC) 活化剂，在血小板中EC50值为 15 nM。 |
| IC50和靶点: | |
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Stasch, J.P., Pacher, P., and Evgenov, O.V.Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary diseaseCirculation123(20),2263-2273(2011)
Stasch, J.P., Schmidt, P., Alonso-Alija, C., et al.NO- and haem-independent activation of soluble guanylyl cyclase: Molecular basis and cardiovascular implications of a new pharmacological principleBr. J. Pharmacol.136,773-783(2002)
Irvine, J.C., Ganthavee, V., Love, J.E., et al.The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophyPLoS One7(11),1-11(2012)
Salloum, F.N., Das, A., Samidurai, A., et al.Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfideAm. J. Physiol. Heart Circ. Physiol.302,H1347-H1354(2012)
Vandendriessche, B., Rogge, E., Goossens, V., et al.The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systemsPLoS One8(9),1-10(2013)
