Linaclotide
Cat. No.：YN321165
| 产品名称: | Linaclotide |
| CAS No.: | 851199-59-2 |
| Chemical Name: | L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine, cyclic (1→6),(2→10),(5→13)-tris(disulfide) |
| Synonyms: | 利那洛肽 |
| 分子量: | 1526.74 |
| 分子式: | C₅₉H₇₉N₁₅O₂₁S₆ |
| SMILES: | O=C([C@@H](NC([C@@](CSSC[C@@H]1N)([H])NC([C@@](CSSC[C@H](N2)C(N[C@H](C(O)=O)CC3=CC=C(O)C=C3)=O)([H])NC([C@@H](NC([C@@H](N4)CCC(O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)CC(N)=O)N6[C@@](C(N[C@H](C(N[C@](CSSC[C@](C4=O)([H])NC1=O)([H])C(NC(C(NCC2=O)=O)[C@H](O)C)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Linaclotide 是一种有效和选择性的鸟苷酸环化酶 C (guanylate cyclase C) 激动剂；开发用于研究便秘型肠易激综合症 (IBS-C) 和慢性便秘。 |
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Bryant, A.P., Busby, R.W., Bartolini, W.P., et al.Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tractLife Sci.86(19-20),760-765(2010)
Castro, J., Harrington, A.M., Hughes, P.A., et al.Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphateGastroenterology145(6),1334-1346(2013)
