Nelociguat
Cat. No.：YN321312
CAS No. ：625115-52-8
| 产品名称: | Nelociguat |
| CAS No.: | 625115-52-8 |
| Chemical Name: | N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-carbamic acid, methyl ester |
| Synonyms: | BAY60-4552 |
| 分子量: | 408.39 |
| 分子式: | C₁₉H₁₇FN₈O₂ |
| SMILES: | O=C(OC)NC1=C(N)N=C(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)N=C1N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nelociguat (BAY60-4552)是一种一氧化氮敏感的可溶性的鸟苷酸环化酶激活物。 |
| IC50和靶点: | |
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Costell, M.H., Ancellin, N., Bernard, R.E., et al.Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stressFront. Pharmacol.3,128(2012)
Oudot, A., Behr-Roussel, D., Poirier, S., et al.Combination of BAY 60-4552 and vardenafil exerts proerectile facilitator effects in rats with cavernous nerve injury: A proof of concept study for the treatment of phosphodiesterase type 5 inhibitor failureEur. Urol.60(5),1020-1026(2011)
Hložek, T., Štícha, M., Bursová, M., et al.Sensitive CE-MS method for monitoring of riociguat and desmethylriociguat levels in human serumElectrophoresis41(18-19),1564-1567(2020)
