Entecavir monohydrate
Cat. No.：YN250517
CAS No. ：209216-23-9
| 产品名称: | Entecavir monohydrate |
| CAS No.: | 209216-23-9 |
| Chemical Name: | 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one, monohydrate |
| Synonyms: | 恩替卡韦 (1水合物); BMS200475 monohydrate; SQ34676 monohydrate |
| 分子量: | 295.29 |
| 分子式: | C₁₂H₁₇N₅O₄ |
| SMILES: | O=C1NC(N)=NC2=C1N=CN2[C@@H]3C([C@H](CO)[C@@H](O)C3)=C.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) 是有选择且有效地HBV抑制剂。在HepG2细胞中的EC50值为3.75 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Innaimo, S.F., Seifer, M., Bisacchi, G.S., et al.Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virusAntimicrob. Agents Chemother.41(7),1444-1448(1997)
Langley, D.R., Walsh, A.W., Baldick, C.J., et al.Inhibition of hepatitis B virus polymerase by entecavirJ. Virol.81(8),3992-4001(2007)
Fung, J., Lai, C.-L., Seto, W.-K., et al.Nucleoside/nucleotide analogues in the treatment of chronic hepatitis BJ. Antimicrob. Chemother.66(12),2715-2725(2011)
Marion, P.L., Salazar, F.H., Winters, M.A., et al.Potent efficacy of entecavir (BMS-200475) in a duck model of hepatitis B virus replicationAntimicrob. Agents Chemother.46(1),82-88(2002)
