Tenofovir Disoproxil Fumarate
Cat. No.：YN250565
CAS No. ：202138-50-9
| 产品名称: | Tenofovir Disoproxil Fumarate |
| CAS No.: | 202138-50-9 |
| Chemical Name: | (5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-2,4,6,8-tetraoxa-5-phosphanonanedioic acid, 1,9-bis(1-methylethyl) ester 5-oxide, (2E)-2-butenedioate |
| Synonyms: | Tenofovir DF |
| 分子量: | 635.51 |
| 分子式: | C₂₃H₃₄N₅O₁₄P |
| SMILES: | O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O.O=C(O)/C=C/C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tenofovir Disoproxil Fumarate (Tenofovir DF) 是核苷酸逆转录酶抑制剂 (nucleotide reverse transcriptase inhibitor)，有潜力用于艾滋病和慢性乙型肝炎的研究。 |
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De Clercq, E.Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infectionsClin. Microbiol. Rev.16(4),569-596(2003)
Robbins, B.L., Srinivas, R.V., Kim, C., et al.Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPAAntimicrob. Agents Chemother.42(3),612-617(1998)
Balzarini, J., Vahlenkamp, T., Egberink, H., et al.Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI miceAntimicrob. Agents Chemother.41(3),611-616(1997)
Balzarini, J., Holy, A., Jindrich, J., et al.Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurineAntimicrob. Agents Chemother.37(2),332-338(1993)
