Tenofovir
Cat. No.：YN250573
CAS No. ：147127-20-6
| 产品名称: | Tenofovir |
| CAS No.: | 147127-20-6 |
| Chemical Name: | P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-phosphonic acid |
| Synonyms: | 替诺福韦; GS 1278; PMPA; TDF |
| 分子量: | 287.21 |
| 分子式: | C₉H₁₄N₅O₄P |
| SMILES: | C[C@@H](OCP(O)(O)=O)CN1C=NC2=C(N)N=CN=C12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tenofovir (GS 1278) 是一种核苷酸逆转录酶 (nucleotide reverse transcriptase) 抑制剂，可用于HIV和慢性乙型肝炎 (Hepatitis B; HBV) 的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Balzarini, J., Vahlenkamp, T., Egberink, H., et al.Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI miceAntimicrob. Agents Chemother.41(3),611-616(1997)
Balzarini, J., Holy, A., Jindrich, J., et al.Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurineAntimicrob. Agents Chemother.37(2),332-338(1993)
Van Gelder, J., Shafiee, M., De Clercq, E., et al.Species-dependent and site-specific intestinal metabolism of ester prodrugsInt. J. Pharm.205(1-2),93-100(2000)
Robbins, B.L., Srinivas, R.V., Kim, C., et al.Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPAAntimicrob. Agents Chemother.42(3),612-617(1998)
