Merimepodib
Cat. No.：YN250577
CAS No. ：198821-22-6
| 产品名称: | Merimepodib |
| CAS No.: | 198821-22-6 |
| Chemical Name: | N-[[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]-carbamic acid, (3S)-tetrahydro-3-furanyl ester |
| Synonyms: | VX-497; MMPD |
| 分子量: | 452.46 |
| 分子式: | C₂₃H₂₄N₄O₆ |
| SMILES: | O=C(O[C@@H]1COCC1)NCC2=CC=CC(NC(NC3=CC=C(C4=CN=CO4)C(OC)=C3)=O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Merimepodib (VX-497) 是非竞争型，有口服活性的肌苷一磷酸脱氢酶 (IMPDH) 抑制剂，具有广谱抗病毒活性。 |
| IC50和靶点: | |
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Sintchak, M.D., and Nimmesgern, E.The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitorsImmunopharmacology47(2-3),163-184(2000)
Tong, X., Smith, J., Bukreyeva, N., et al.Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogensAntiviral Res.149,34-40(2018)
Jain, J., Almquist, S.J., Shlyakhter, D., et al.VX-497: A novel, selective IMPDH inhibitor and immunosuppressive agentJ. Pharm. Sci.90(5),625-637(2001)
Decker, C.J., Heiser, A.D., Chaturvedi, P.R., et al.The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in miceDrugs Exp. Clin. Res.27(3),89-95(2001)
