Adefovir dipivoxil
Cat. No.：YN250970
| 产品名称: | Adefovir dipivoxil |
| CAS No.: | 142340-99-6 |
| Chemical Name: | 2,2-dimethyl-propanoic acid, 1,1′-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester |
| Synonyms: | 阿德福韦酯; GS 0840 |
| 分子量: | 501.47 |
| 分子式: | C₂₀H₃₂N₅O₈P |
| SMILES: | NC1=C2N=CN(CCOCP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C2=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Adefovir dipivoxil 是一种腺苷类似物，是核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂 Adefovir 的口服前药。Adefovir dipivoxil 对 Lamivudine 耐药株和野生型菌株均有抑制作用。 |
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Liu, L.J., Wang, J.H., Du, S.C., et al.rtE218G, a novel hepatitis B virus mutation with resistance to adefovir dipivoxil in patients with chronic hepatitis BJ. Viral Hepat.17(Suppl. 1),66-72(2010)
Fu, X., Jiang, S., Li, C., et al.Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activityBioorg. Med. Chem. Lett.17(2),465-470(2007)
Morrey, J.D., Korba, B.E., Beadle, J.R., et al.Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivoAntimicrob. Agents Chemother.53(7),2865-2870(2009)
