Adefovir
Cat. No.：YN251364
| 产品名称: | Adefovir |
| CAS No.: | 106941-25-7 |
| Chemical Name: | P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-phosphonic acid |
| Synonyms: | 阿德福韦; GS-0393; PMEA |
| 分子量: | 273.19 |
| 分子式: | C₈H₁₂N₅O₄P |
| SMILES: | NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Adefovir (GS-0393) 是一种单磷酸腺苷类似物抗病毒剂，在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA聚合酶。Adefovir 在 HepG2.2.15 细胞系中对HBV的IC50为 0.7 μM。Adefovir 对多种病毒(包括HBV和疱疹病毒)具有良好的抗病毒活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Arimilli, M.N., Dougherty, J.P., Cundy, K.C., et al.Orally bioavailable acyclic nucleoside phosphonate prodrugs: Adefovir dipivoxil and bis(POC)PMPAAdvances in Antiviral Drug Design3,69-91(1999)
Laizure, S.C., Herring, V., Hu, Z., et al.The role of human carboxylesterases in drug metabolism: Have we overlooked their importance?Pharmacotherapy33(2),210-222(2013)
Holý, A., Votruba, I., Masojídková, M., et al.6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activityJ. Med. Chem.45(9),1918-1929(2002)
Rossi, L., Dominici, S., Serafini, S., et al.Pharmacokinetic and antiretroviral activity in mice of oral [P1,P2-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenineJ. Antimicrob. Chemother.50(3),365-374(2002)
Naesens, L., Balzarini, J., Bischofberger, N., et al.Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenineAntimicrob. Agents Chemother.40(1),22-28(1996)
