Osalmid
Cat. No.：YN251402
| 产品名称: | Osalmid |
| CAS No.: | 526-18-1 |
| Chemical Name: | 2-hydroxy-N-(4-hydroxyphenyl)-benzamide |
| Synonyms: | 羟苯水杨胺; Oxaphenamide; 4'-Hydroxysalicylanilide |
| 分子量: | 229.23 |
| 分子式: | C₁₃H₁₁NO₃ |
| SMILES: | O=C(NC1=CC=C(O)C=C1)C2=CC=CC=C2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Osalmid是核糖核苷酸还原酶小亚基M2（RRM2）的靶向化合物；抑制核糖核苷酸还原酶活性的IC50值为8.23 μM。 |
| IC50和靶点: | |
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Liu, X., Xu, Z., Hou, C., et al.Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 proteinBiochem. Pharmacol.103,118-128(2016)
Wu, Z., Zhan, Y., Wang, L., et al.Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cellsBiomed. Pharmacother.130,110556(2020)
Tang, Q., Wu, L., Xu, M., et al.Osalmid, a novel identified RRM2 inhibitor, enhances radiosensitivity of esophageal cancerInt. J. Radiat. Oncol. Biol. Phys.108(5),1368-1379(2020)
