Marein
Cat. No.：YN420317
CAS No. ：535-96-6
规格
价格(RMB)
库存
| 产品名称: | Marein |
| CAS No.: | 535-96-6 |
| Chemical Name: | (2E)-3-(3,4-dihydroxyphenyl)-1-[4-(β-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-2-propen-1-one |
| Synonyms: | 马里苷,马里甙 |
| 分子量: | 450.39 |
| 分子式: | C₂₁H₂₂O₁₁ |
| SMILES: | O=C(C1=CC=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)C(O)=C1O)/C=C/C3=CC=C(O)C(O)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Marein 通过减少对线粒体功能的损害和AMPK信号通路的激活而具有神经保护作用。Marein 通过 CaMKK/AMPK/GLUT1 促进葡萄糖摄取，通过 IRS/Akt/GSK-3β 增加糖原合成，并通过 Akt/FoxO1 减少糖异生，从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。Marein 是一种HDAC抑制剂，IC50为 100 µM。Marein 具有有益的抗氧化，降压，降血脂和抗糖尿病作用。 |
| IC50和靶点: | |
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Wang, W., Chen, W., Yang, Y., et al.New phenolic compounds from Coreopsis tinctoria Nutt. and their antioxidant and angiotensin i-converting enzyme inhibitory activitiesJ. Agric. Food Chem63(1),200-207(2015)
Yang, E.B., Guo, Y.J., Zhang, K., et al.Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivativesBiochim Biophys Acta.1550(2),144-152(2001)
Guo, Y., Ran, Z., Zhang, Y., et al.Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose-treated HK-2 cellsBiomed. Pharmacother.131,110684(2020)
