ZD7288
Cat. No.：YN360076
CAS No. ：133059-99-1
| 产品名称: | ZD7288 |
| CAS No.: | 133059-99-1 |
| Chemical Name: | N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine, monohydrochloride |
| Synonyms: | ICI D7288 |
| 分子量: | 292.81 |
| 分子式: | C₁₅H₂₁ClN₄ |
| SMILES: | [H]Cl.C/N=C1C=C(N(CC)C2=CC=CC=C2)N=C(C)N/1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ZD7288 (ICI D7288) 是一种有选择性的超极化激活的环核苷酸门控 (HCN) 通道阻断剂。 |
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Herrmann, S., Schnorr, S., and Ludwig, A.HCN channels-modulators of cardiac and neuronal excitabilityInt. J. Mol. Sci.16(1),1429-1447(2015)
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McClure, K.J., Maher, M., Wu, N., et al.Discovery of a novel series of selective HCN1 blockersBioorg. Med. Chem. Lett.21,5197-5201(2011)
BoSmith, R.E., Briggs, I., and Sturgess, N.C.Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cellsBr. J. Pharmacol.110(1),343-349(1993)
Rouse, W., and Johnson, I.R.Haemodynamic actions of a novel sino-atrial node function modulator, ZENECA ZD7288, in the anaesthetized dog: A comparison with zatebradine, atenolol and nitrendipineBr. J. Pharmacol.113(3),1064-1070(1994)
Luo, L., Chang, L., Brown, S.M., et al.Role of peripheral hyperpolarization-activated cyclic nucleotidemodulated channel pacemaker channels in acute and chronic pain models in the ratNeuroscience144,1477-1485(2007)
Chen, Y., Lin, C., Tang, Y., et al.ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like ratsWorld J. Gastroenterol.20(8),2091-2097(2014)
