Zatebradine hydrochloride
Cat. No.：YN360423
| 产品名称: | Zatebradine hydrochloride |
| CAS No.: | 91940-87-3 |
| Chemical Name: | 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride |
| Synonyms: | UL-FS-49; UL-FS-49CL |
| 分子量: | 493.04 |
| 分子式: | C₂₆H₃₇ClN₂O₅ |
| SMILES: | O=C1N(CCCN(CCC2=CC=C(OC)C(OC)=C2)C)CCC3=CC(OC)=C(OC)C=C3C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zatebradine (UL-FS-49 (free base)) 是一种高效的HCN Channel抑制剂，其IC50值为 1.96 µM。Zatebradine 会阻止通过人类HCN1，HCN2，HCN3和HCN4通道的缓慢内向电流，其IC50值分别为 1.83 µM，2.21 µM，1.90 µM 和 1.88 µM。 |
| IC50和靶点: | |
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Stieber, J., Wieland, K., Stöckl, G., et al.Bradycardic and proarrhythmic properties of sinus node inhibitorsMol. Pharmacol.69(4),1328-1337(2006)
Melchiorre, M., Del Lungo, M., Guandalini, L., et al.Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockersJ. Med. Chem.53(18),6773-6777(2010)
Satoh, T.O., and Yamada, M.Multiple inhibitory effects of zatebradine (UL-FS 49) on the electrophysiological properties of retinal rod photoreceptorsPflugers Arch.443(4),532-540(2002)
BoSmith, R.E., Briggs, I., and Sturgess, N.C.Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cellsBr. J. Pharmacol.110(1),343-349(1993)
