Pibrentasvir
Cat. No.：YN250067
CAS No. ：1353900-92-1
| 产品名称: | Pibrentasvir |
| CAS No.: | 1353900-92-1 |
| Chemical Name: | N,N'-[[(2R,5R)-1-[3,5-difluoro-4-[4-(4-fluorophenyl)-1-piperidinyl]phenyl]-2,5-pyrrolidinediyl]bis[(6-fluoro-1H-benzimidazole-5,2-diyl)-(2S)-2,1-pyrrolidinediyl[(1S)-1-[(1R)-1-methoxyethyl]-2-oxo-2,1-ethanediyl]]]bis-carbamic acid, dimethyl ester |
| Synonyms: | ABT-530 |
| 分子量: | 1113.18 |
| 分子式: | C₅₇H₆₅F₅N₁₀O₈ |
| SMILES: | FC(C=C(N=C([C@H](CCC1)N1C([C@H]([C@@H](C)OC)NC(OC)=O)=O)N2)C2=C3)=C3[C@@H]4N(C5=CC(F)=C(N6CCC(C7=CC=C(F)C=C7)CC6)C(F)=C5)[C@@H](C(C=C(NC([C@H](CCC8)N8C([C@H]([C@@H](C)OC)NC(OC)=O)=O)=N9)C9=C%10)=C%10F)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pibrentasvir 是一种新型的泛基因型丙型肝炎病毒 (HCV)NS5A抑制剂，对来自基因型 1 至 6 含有 NS5A 的 HCV 复制子的EC50范围为 1.4 至 5.0 pM。 |
| IC50和靶点: | |
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Wagner, R.R., Randolph, J.T., Patel, S.V., et al.Highlights of the structure-activity relationships of benzimidazole linked pyrrolidines leading to the discovery of the hepatitis C virus NS5A inhibitor pibrentasvir (ABT-530)J. Med. Chem.61(9),4052-4066(2018)
Ng, T.I., Krishnan, P., Pilot-Matias, T., et al.In vitro antiviral activity and resistance profile of the next-generation hepatitis C virus NS5A inhibitor pibrentasvirAntimicrob. Agents Chemother.61(5),e02558-02516(2017)
