Daclatasvir dihydrochloride
Cat. No.：YN250107
CAS No. ：1009119-65-6
| 产品名称: | Daclatasvir dihydrochloride |
| CAS No.: | 1009119-65-6 |
| Chemical Name: | BMS 790052-05; N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic Acid C,C'-Dimethyl Ester Hydrochloride (1:2) |
| Synonyms: | 盐酸达拉他韦; BMS-790052 dihydrochloride; EBP 883 dihydrochloride |
| 分子量: | 811.80 |
| 分子式: | C₄₀H₅₂Cl₂N₈O₆ |
| SMILES: | O=C(N1CCC[C@H]1C2=NC=C(C3=CC=C(C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C([C@H](C(C)C)NC(OC)=O)=O)C=C3)N2)[C@H](C(C)C)NC(OC)=O.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) 是一种有效的具有口服活性的HCV NS5A蛋白抑制剂，多种HCV复制子基因型的EC50范围为 9-146 pM。Daclatasvir dihydrochloride 也是有机阴离子转运多肽 1B (OATP1B) 和OATP1B3抑制剂，IC50分别为 1.5 µM 和 3.27 µM。 |
| IC50和靶点: | |
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Song, B., et. al.: Zhongguo Xinyao Zazhi, 22, 2679 (2013)
Gao, M., et al.: Nature, 465(7294), 96 (2010)
Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010)
