U18666A
Cat. No.：YN250144
CAS No. ：3039-71-2
| 产品名称: | U18666A |
| CAS No.: | 3039-71-2 |
| Chemical Name: | 3β-[2-(diethylamino)ethoxy]-androst-5-en-17-one, monohydrochloride |
| Synonyms: | U18 |
| 分子量: | 424.06 |
| 分子式: | C₂₅H₄₂ClNO₂ |
| SMILES: | C[C@@]12[C@]3([H])[C@](CC=C1C[C@@H](OCCN(CC)CC)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | U18666A，一种细胞内胆固醇转运 (cholesterol transport) 抑制剂，抑制埃博拉病毒，登革热病毒和人类丙型肝炎病毒的复制。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Koh, C.H.V., and Cheung, N.S.Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann-Pick disease type C and Alzheimer's diseaseCell. Signal.18(11),1844-1853(2006)
Tabas, I.Apoptosis and plaque destabilization in atherosclerosis: The role of macrophage apoptosis induced by cholesterolCell Death Differ.11,S12-S16(2004)
Feng, B., Yao, P.M., Li, Y., et al.The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesNat. Cell Biol.5(9),781-792(2003)
