Sofosbuvir
Cat. No.：YN250618
CAS No. ：1190307-88-0
| 产品名称: | Sofosbuvir |
| CAS No.: | 1190307-88-0 |
| Chemical Name: | N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine, 1-methylethyl ester |
| Synonyms: | 索非布韦; GS-7977; PSI-7977 |
| 分子量: | 529.45 |
| 分子式: | C₂₂H₂₉FN₃O₉P |
| SMILES: | O=C1N([C@H]2[C@]([C@H](O)[C@@H](CO[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)O2)(C)F)C=CC(N1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sofosbuvir (GS-7977) 是HCVRNA复制抑制剂，EC50为 92 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Murakami, E., Tolstykh, T., Bao, H., et al.Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977J. Biol. Chem.285(45),34337-34347(2010)
Mesci, P., de Souza, J.S., Martin-Sancho, L., et al.SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with SofosbuvirPLoS Biol.20(11),e3001845(2022)
