Elbasvir
Cat. No.：YN250656
CAS No. ：1370468-36-2
| 产品名称: | Elbasvir |
| CAS No.: | 1370468-36-2 |
| Chemical Name: | N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-carbamic acid, C,C'-dimethyl ester |
| Synonyms: | MK-8742 |
| 分子量: | 882.02 |
| 分子式: | C₄₉H₅₅N₉O₇ |
| SMILES: | O=C([C@H](C(C)C)NC(OC)=O)N(CCC1)[C@@H]1C(N2)=NC=C2C(C=C3)=CC4=C3C5=CC6=CC(C7=CN=C([C@H]8N(C([C@H](C(C)C)NC(OC)=O)=O)CCC8)N7)=CC=C6N5[C@H](C9=CC=CC=C9)O4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elbasvir (MK-8742) 是丙型肝炎病毒非结构蛋白5A (HCV NS5A) 抑制剂， 对基因型1a，1b和2a的EC50分别为4，3 和3 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lahser, F.C., Bystol, K., Curry, S., et al.The combination of grazoprevir, a Hepatitis C virus (HCV) NS3/4A protease inhibitor, and elbasvir, an HCV NS5A inhibitor, demonstrates a high genetic barrier to resistance in HCV genotype 1a repliconsAntimicrob. Agents Chemother.60(5),2954-2964(2016)
McGivern, D.R., Masaki, T., Williford, S., et al.Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitorsGastroenterology147(2),453-462(2014)
Asante-Appiah, E., Curry, S., McMonagle, P., et al.Antiviral activity and resistance analysis of NS3/4A protease inhibitor grazoprevir and NS5A inhibitor elbasvir in Hepatitis C virus GT4 repliconsAntimicrob. Agents Chemother.61(7),e00363-e00417(2017)
Liu, R., Curry, S., McMonagle, P., et al.Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor elbasvirAntimicrob. Agents Chemother.59(11),6922-6929(2015)
