Mizoribine
Cat. No.：YN250732
CAS No. ：50924-49-7
| 产品名称: | Mizoribine |
| CAS No.: | 50924-49-7 |
| Chemical Name: | 5-hydroxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| Synonyms: | 咪唑立宾; NSC 289637; HE 69 |
| 分子量: | 259.22 |
| 分子式: | C₉H₁₃N₃O₆ |
| SMILES: | O[C@@H]1[C@@H](CO)O[C@@H](N2C(O)=C(C(N)=O)N=C2)[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mizoribine (NSC 289637) 抑制HCVRNA 复制，具有抗 HCV 活性，IC50约为 100 μM。Mizoribine 是一种免疫抑制剂。Mizoribine 抑制IMPDH。Mizoribine 抑制SARS-CoV复制，对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50分别为 3.5 μg/mL 和 16 μg/mL。 |
| IC50和靶点: | |
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Turka, L.A., Dayton, J., Singclair, G., et al.Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribineJ. Clin. Invest.87(3),940-948(1991)
Dayton, J.S., Turka, L.A., Thompson, C.B., et al.Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolismMol. Pharmacol.41(4),671-676(1992)
Naka, K., Ikeda, M., Abe, K., et al.Mizoribine inhibits hepatitis C virus RNA replication: Effect of combination with interferon-αBiochem. Biophys. Res. Commun.330(3),871-879(2005)
Kikuchi, Y., Imakiire, T., Yamada, M., et al.Mizoribine reduces renal injury and macrophage infiltration in non-insulin-dependent diabetic ratsNephrol. Dial. Transplant.20(8),1573-1581(2005)
