Boceprevir
Cat. No.：YN370242
CAS No. ：394730-60-0
| 产品名称: | Boceprevir |
| CAS No.: | 394730-60-0 |
| Chemical Name: | (1R,2S,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-3-azabicyclo[3.1.0]hexane-2-carboxamide |
| Synonyms: | 波普瑞韦; EBP 520; SCH 503034 |
| 分子量: | 519.68 |
| 分子式: | C₂₇H₄₅N₅O₅ |
| SMILES: | O=C(N1[C@@H]([C@@]2([H])C(C)([C@]2(C1)[H])C)C(NC(C(C(N)=O)=O)CC3CCC3)=O)[C@@H](NC(NC(C)(C)C)=O)C(C)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Boceprevir 是一种口服有效的选择性的HCV NS3 protease抑制剂，酶实验中Ki为 14 nM，在含细胞体系的复制实验中，EC90为 350 nM。 |
| IC50和靶点: | |
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Malcolm, B.A., Liu, R., Lahser, F., et al.SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cellsAntimicrob. Agents Chemother.50(3),1013-1020(2006)
Maren, T.H.Carbonic anhydrase: Chemistry, physiology, and inhibitionPhysiol. Rev.47(4),595-781(1967)
Ma, C., Sacco, M.D., Hurst, B., et al.Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteaseCell Res.30(8),678-692(2020)
