Danoprevir
Cat. No.：YN370243
CAS No. ：850876-88-9
| 产品名称: | Danoprevir |
| CAS No.: | 850876-88-9 |
| Chemical Name: | 4-fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e] pyrrolo[1,2-a] |
| Synonyms: | 丹诺普韦; ITMN-191; R7227; RO5190591; RG7227 |
| 分子量: | 731.83 |
| 分子式: | C₃₅H₄₆FN₅O₉S |
| SMILES: | O=S(NC([C@@]1(NC([C@]2([H])C[C@@H](OC(N3CC4=C(C3)C=CC=C4F)=O)CN2C5=O)=O)C[C@]1(/C=C/CCCCC[C@@H]5NC(OC(C)(C)C)=O)[H])=O)(C6CC6)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Danoprevir (ITMN-191) 是一种具有口服活性的NS3/4A蛋白酶抑制剂，IC50值为 0.29 nM。与其他 53 种蛋白酶 (IC50高于 10 μM) 相比，对 NS3/4A 具有高选择性。Danoprevir (ITMN-191) 抑制 HCV 基因型 1a, 1b, 4, 5, 6 (IC50s=0.2-0.4 nM) 和 2b, 3a (IC50s=1.6, 3.5 nM)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Seiwert, S.D., Andrews, S.W., Jiang, Y., et al.Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227)Antimicrob. Agents Chemother.52(12),4432-4441(2008)
